DRUG ANALYSIS III AND FOOD ANALYSIS
ANALISI DEI FARMACI III E DEGLI ALIMENTI
|Lecturer||Office hours for students|
|Annalida Bedini||All weekdays, except Saturdays, by appointment.|
|Teaching in foreign languages|
Course with optional materials in a foreign language
This course is entirely taught in Italian. Study materials can be provided in the foreign language and the final exam can be taken in the foreign language.
Assigned to the Degree Course
|Date||Time||Classroom / Location|
The course, intended to provide theoretical and practical knowledge on instrumental techniques used for the determination of the purity of a drug, for the qualitative detection and for the determination of the amount of the active ingredients in a more or less complex systems, for the determination of the stability of a drug and for checks aimed at the search and identification of metabolites.
Control of the quality of analytical methods.
Chemical and physical properties of drugs molecules.
Titrimetric and chemical analysis methods .
UV/visible spectroscopy: instrumentation; qualitative analysis: correlation UV spectrum and chemical structure; effect of pH and solvent. Quantitative analysis: Lambert-Beer law, construction of calibration line.
Infrared Spectroscopy: instrumentation, pharmaceutical analysis applications. Near infrared spectroscopy.
Atomic Absorbtion Spectrophotometry and Atomic Emission Spectrophotometry: instrumentation and applications.
Molecular Emission Spectroscopy. Fluorescence Spectroscopy: instrumentation and applications.
Mass spectrometry. Ionization sources: EI, CI, FAB, ESI, APCI and MALDI. Analyzers: magnetic sector, single and triple quadrupole, time of flight and ion trap. Applications to pharmaceutical and biological sciences.
Chromatographic techniques. Instrumentation and applications: TLC, HPLC and GC. Detectors for HPLC: UV-Vis, UV/vis photodiode, fluorimetric, refractometric, electrochemical and polarimetric. GC detectors: FID, thermal conductivity, electron capture. Qualitative analysis and quantitative techniques in chromatography.
Capillary electrophoresis: instrumentation and applications.
Extraction methods in pharmaceutical analysis.
Analysis of herbal medicines, food, nutraceutical and homeopathic preparations.
Organic Chemistry I, Drug Analysis I and Drug Analysis II
Learning Achievements (Dublin Descriptors)
Knowledge and understanding. The student should have acquired the theoretical and practical knowledge on instrumental techniques used for the determination of the purity of a drug, for the qualitative detection and for the determination of the amount of the active ingredients in a more or less complex systems, for the determination of the stability of a drug and for checks aimed at the search and identification od metabolites.
Applying knowledge and understanding. The student will be able to apply the knowledge acquired during the course, and then be able to conduct qualitative and quantitative instrumental analysis of substances of pharmaceutical interest in more or less complex systems obtaining valid results. The student must also be able to plan and implement an analytical method.
Making judgements. The student must show independence of judgment in the interpretation of the experimental data and of the obtained results.
Communication skills. After completing the course the student will be able to present what he has learned using appropriate terminology for the purpose of scientific communication regarding methodologies and issues concerning the analysis of compounds of pharmaceutical interest. The student will be able to organize and present clear and complete reports.
Learning skills. The student will have developed the learn ability useful to continuously update his knowledge and will be able to use it in order to face new analytical issues.
The teaching material prepared by the lecturer in addition to recommended textbooks (such as for instance slides, lecture notes, exercises, bibliography) and communications from the lecturer specific to the course can be found inside the Moodle platform › blended.uniurb.it
There are no activities to support teaching.
Didactics, Attendance, Course Books and Assessment
Lectures (3 cfu) and laboratory (3 cfu) exercises for groups and individuals
The frequency of laboratory exercises is mandatory. To gain access to the laboratory is necessary to have passed the examination of Organic Chemistry I and attended Drugs analysis II
- Course books
D. G. Watson Analisi Farmaceutica, terza edizione, edra ed.
Oral examination, subject to approval of the practical part of the workshop.
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