The objectives of the course are to provide students with a good understanding of the general aspects of organic chemistry, with particular reference to nomenclature, structural features of functional groups. A particular focus will be on the structure, properties and reactivity of carbohydrates, amino acids, proteins and lipids.

Introduction to Organic Chemistry. Chemical bonds and carbon hybridization. Electronegativity. Acidity and basicity according to Brønsted-Lowry and Lewis theories.
Alkanes and cycloalkanes: structural and electronic aspects, nomenclature, constitutional isomerism. Cycloalkanes.
Alkenes: structure, nomenclature and isomeric E / Z. Main organic reactions, nucleophiles and electrophiles. Electrophilic addition reactions: hydrohalogenation-reaction mechanism. Intermediate reaction. Carbocations and their stability.
Inductive effect. Hydration, halogenation. Markovnikov’s rule.
Alkynes: structure and nomenclature.
Benzene and aromatic compounds. Aromatic concept. Nomenclature of aromatic systems. Electrophilic aromatic substitution (SEAr): mechanism. Halogenation of benzene: mechanism. Effect of substituents on reactivity and orientation. Activating and deactivating groups. Mesomeric effect and inductive effect. Substituted benzenes.
Alcohols and ethers. Structure and nomenclature. Phenols: acidity. Epoxides.
Stereoisomerism. Chirality, enantiomers. Configuration notation R, S. Cahn-Prelog-Ingold rules. Optical activity, polarimetry. Molecules with two or more stereocenters. Diastereoisomers. Physical and chemical properties of stereoisomers. Racemates. Meso compounds.
Aldehydes and ketones. Structure and nomenclature. Reaction of carbonyl carbon and acidity of hydrogen in alpha position. Nucleophilic addition reactions: mechanism of nucleophilic addition. Addition of alcohols: formation of emiacetals and acetals. Keto-enol tautomerism. Aldehyde condensation.
Carboxylic acids. Structure, nomenclature, acidity, chemical-physical properties. Derivatives of carboxylic acids: acyl chlorides, anhydrides, esters, amides. Fischer Esterification. Esters hydrolysis under basic conditions.
Amines. Structure, classification and nomenclature. Basicity. Aliphatic and aromatic amine basicity scale.
Carbohydrates: aldoses and ketoses. Monosaccharides: glucose and fructose structure. Stereochemistry and relative configuration of sugars. L and D sugars. Fischer and Haworth projections. Open and closed structure. Glucose cyclic hemiacetal and hemiketal. Anomeric effect.
Amino acids. Structure, acid-base properties and zwitterionic form. Relative configuration. Classification of protein amino acids. The peptide bond. Dipeptide.
Triglycerides: fats and oils. Soap and micellar aggregates. Saturated and unsaturated fatty acids. Catalytic hydrogenation of oils. Isomerization cis/trans.

The student should have passed the General and Inorganic Chemistry exam.

Knowledge and understanding skills. The student will need to know the principles underlying the chemical bond, the nomenclature rules of organic compounds, be able to highlight the relationship between formulas, spatial structures and molecular properties.
The student will have to know the basic concepts of acidity and basicity according to Lewis rules, the stereochemistry, knowing and distinguishing enantiomers and the differences with the diastereo-isomers; the student will also have to master the Fisher Formulas.
The student must be able to identify the various functional groups, distinguishing between an aliphatic and an aromatic compound, the interactions between functional groups, their preparation and reactivity. The student will have to know the main biomolecules and relationships that bind the various functional groups that compose them and reactivity.
These skills will be verified through a written test and oral questions.
Ability to apply knowledge and understanding. The student should be able to use the various methods to describe an organic compound, nomenclature, symbols to express reaction mechanisms, resonance formulas and distinguish their energy weight. It will also apply the knowledge acquired to interpret basic acid / base properties of organic compounds.
The student will be able to synthesise and recognize organic compounds by applying the major stru-ctural and reactionary properties and the most important synthesis methods.
These skills will be evaluated through a written test.
Judgment autonomy. The student should be able to critically evaluate the structure and properties of an organic compound, both in terms of molecular complexity, stereochemistry, acid / base and reaction properties.
The knowledge acquired in the study of the different functional groups will find their full applica-tion in the student's ability to evaluate in their complexity biomolecular systems of interest for the purposes of the Study Course.
These skills will be verified both with the written test and with targeted oral application questions.
Communicative Skills. The student should be able to describe the structural and reactive concepts learned during the course by expressing it clearly, with appropriate terms and examples.
Learning ability. The student will have to be able to construct his or her scientific growth path in a critical and autonomous way, using the teaching material provided by the teacher in the form of texts and slides, as well as the in-depth material that he or she will be able to obtain. These skills, as far as possible, will be stimulated by the teacher by offering insights and providing exercises to be solved, which will then be explained and discussed during the lessons.

The teaching material prepared by the lecturer in addition to recommended textbooks (such as for instance slides, lecture notes, exercises, bibliography) and communications from the lecturer specific to the course can be found inside the Moodle platform › blended.uniurb.it

Teaching

Lectures with classroom exercises

Course books

AA.VV. "Chimica Organica Essenziale" by B. Botta Edi Ermes 2012
W. H. Brown, T. Poon "Introduzione alla Chimica Organica", IV Edizione, Edises, 2011
Copy of slides of the lessons available in the Moodle platform › blended.uniurb.it

Assessment

The oral exam will be preceded by a written test, which involves the solution of simple exercises to assess the student's ability to correlate the various issues of the program.
The vote assigned to the writing is determined by the number of exercises carried out. The written test will be considered passed by a vote of 18/30.
The oral test will have the purpose to determine the final vote.

Disabilità e DSA

Le studentesse e gli studenti che hanno registrato la certificazione di disabilità o la certificazione di DSA presso l'Ufficio Inclusione e diritto allo studio, possono chiedere di utilizzare le mappe concettuali (per parole chiave) durante la prova di esame.

A tal fine, è necessario inviare le mappe, due settimane prima dell’appello di esame, alla o al docente del corso, che ne verificherà la coerenza con le indicazioni delle linee guida di ateneo e potrà chiederne la modifica.