The aim of the course is the analysis of chemical processes in biopharmaceutical field by means of physico-chemical methods, in order to verify their feasibility and optimization and to study the properties and the troubleshooting which involve chemicals, their structure and interactions.

PROCESSES AND REACTIVITY: Energies involved in biopharmaceutical chemical processes  determining their feasibility and optimization. The thermodynamics in chemical processes and the need to define thermodynamic functions such as enthalpy, entropy and free energy or chemical potential and the principles that correlate with each other and with the system variables. State of balance and out of balance. Examples of processes in which these principles apply.Systems with single and multi-components, phase equilibria and phase diagrams. Solutions, standard biological balance of the apportionment; extraction and purification, surface tension, surfactants; adsorption.Reaction rate and chemical kinetics. Order and molecularity. Arrhenius equation. Transposed through biological membranes. Homogeneous and heterogeneous catalysis and enzyme action.Solid state structure and related properties.
PHYSICO-CHEMICAL METHODS: Principles of quantochimica which are at the basis of the interaction of radiation with matter. Intermolecular forces, interactions and bonds, molecular recognition in biological systems. Spectroscopic techniques: atomic and molecular spectroscopy. Theoretical and experimental basis of UV-Vis, fluorescence, IR and RAMAN and MRIs.

no

- The student must show the possession of the mastery of basic knowledge about the basic concepts related to physico-chemical investigation techniques and to assess biopharmacological processes.
- The student must show an understanding of the concepts and theories provided by the course; he/she will provide examples of evaluation of simple processes that identify interactions of biomolecules and drugs with use of techniques such as UV-Vis, fluorescence, IR, Raman, and MRIs.
- The student must show the possession of the ability to use knowledge and concepts that allow to reason according to the specific logic of the discipline. Must be able, in particular, to identify methodologies that allow to know the physico-chemical processes that involve drugs and biomolecules.

The teaching material prepared by the lecturer in addition to recommended textbooks (such as for instance slides, lecture notes, exercises, bibliography) and communications from the lecturer specific to the course can be found inside the Moodle platform › blended.uniurb.it

Eventual practical exercises will be performed by Dr. Michela Cangiotti and Dr. Alberto Fattori

Teaching

lectures and exercises

Attendance

no

Course books

handouts available on-line

Reference text: Physical Chemistry, Atkins

Assessment

Oral examination

Disabilità e DSA

Le studentesse e gli studenti che hanno registrato la certificazione di disabilità o la certificazione di DSA presso l'Ufficio Inclusione e diritto allo studio, possono chiedere di utilizzare le mappe concettuali (per parole chiave) durante la prova di esame.

A tal fine, è necessario inviare le mappe, due settimane prima dell’appello di esame, alla o al docente del corso, che ne verificherà la coerenza con le indicazioni delle linee guida di ateneo e potrà chiederne la modifica.

Teaching

Students can study on texts and handouts asking for clarifications to the teacher

Attendance

no

Course books

handouts available on-line

Reference text: Physical Chemistry, Atkins

Assessment

Oral Examination

Disabilità e DSA

Le studentesse e gli studenti che hanno registrato la certificazione di disabilità o la certificazione di DSA presso l'Ufficio Inclusione e diritto allo studio, possono chiedere di utilizzare le mappe concettuali (per parole chiave) durante la prova di esame.

A tal fine, è necessario inviare le mappe, due settimane prima dell’appello di esame, alla o al docente del corso, che ne verificherà la coerenza con le indicazioni delle linee guida di ateneo e potrà chiederne la modifica.