DRUG ANALYSIS II
ANALISI DEI FARMACI II
|Lecturer||Office hours for students|
|Gianfranco Favi||By appointment from Monday to Friday|
Assigned to the Degree Course
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The course aims to provide skills and mastery of theoretical and practical quali- and quantitative chemical analysis of organic substances of pharmaceutical interest, recorded and not, in the European Pharmacopoeia (E.P.)
- State of matter and chemical-physical characteristics
- Solubility, dissolution process, types of solvents, structure-solubility relationships, solubility assay, pKa, solubility in acqueous environment at varying pH
- Determination of some physical-chemical constants: melting point, boiling point, melting point in the mixture
- Qualitative elemental analysis (C, H, N, S, P, X)
- Analysis of recognition of metal-organic compounds
- General assays and recognition of functional groups
- Scheme for the systematic identification of an unknown organic substance
- Structural determination of organic substances: elemental analysis, IR and UV-VIS spectroscopy
- Applications on organic substances of the acid-base, argentometric, complexometric, redox, iodometric and diazotization titration. Recognition essay and purity of the main pharmaceutical structures according to the monographs of F.U. and E.P.
General and Inorganic Chemistry fundamentals
Learning Achievements (Dublin Descriptors)
- Knowledge of traditional analytical techniques in organic and inorganic chemistry; understanding of more recent instrumental tecniques of organic qualitative analysis applied to organic and inorganic substances
- Applying traditional and instrumental analytical tecniques to the determination of unknown compound belonging to the European Pharmacopoeia (E.P.)
- Acquisition of skills to undertake analysis of unknown substances as autonomously and independently as possible
- Development of communication skills suited to the presentation of the collected data during the analysis of unknown substances. Ability to report the results in an analytical and synthetic way
- The student at the end of the course, will possess enough understanding and knowledge to perform qualitative analysis of unknown organic and inorganic compounds belonging to the European Pharmacopoeia (E.P.). Moreover, the student will be able to continuously updating his background through the study of the literature, database, etc.
The teaching material prepared by the lecturer in addition to recommended textbooks (such as for instance slides, lecture notes, exercises, bibliography) and communications from the lecturer specific to the course can be found inside the Moodle platform › blended.uniurb.it
Didactics, Attendance, Course Books and Assessment
Lectures and individual laboratory experiences
The frequency of laboratory experiences is mandatory. To gain access to the laboratory is necessary to have passed the exam of General and Inorganic Chemistry.
- Course books
- A. Carta, M. G. Mamolo, F. Novelli, S. Piras, Analisi Farmaceutica Qualitativa (Analisi qualitativa organica ed inorganica non strumentale), EdiSES Ed.
- For consultation: Brown Foote Iverson, Chimica Organica, EdiSES Ed. (II anno, Organic Chemistry I)
- D. G. Watson, Analisi Farmaceutica EdiSES Ed. (III anno, Drug Analysis III)
- Italian Pharmacopoeia X Ed.
Oral examination after preliminary test with the approval of the practical part of the laboratory
The frequency at lectures is strongly recommended
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