Università degli Studi di Urbino Carlo Bo / Portale Web di Ateneo


BIOCHEMISTRY
BIOCHIMICA

A.Y. Credits
2018/2019 8
Lecturer Email Office hours for students
Michele Guescini
Teaching in foreign languages
Course with optional materials in a foreign language English
This course is entirely taught in Italian. Study materials can be provided in the foreign language and the final exam can be taken in the foreign language.

Assigned to the Degree Course

Sport, Health and Physical Exercise (L-22)
Curriculum: PERCORSO COMUNE
Giorno Orario Aula
Giorno Orario Aula

Learning Objectives

The course aims to provide students with basic knowledge on fundamental processes of the biochemical mechanisms that regulate cellular metabolic activities with particular attention to energy metabolism and to the molecular basis of adaptation to physical exercise.

Program

The course will address the following topics in the order below:

First part

Principles of bioenergetics and thermodynamics. Cells and sources of free energy.

Paired reactions and free energy variations The transfer of phosphoric groups and ATP.

Free energy standard of phosphorylated compounds (Fosfoenolpyruvate, 1,3 diphosphoglycerate, Phosphocreatine) and thioesters (Acetyl Coenzyme A)

ATP provides energy by group transfer, not by simple hydrolysis

Enzymes

Classification of enzymes. How enzymes work: enzymatic kinetics

Michaelis's equation - Menten Vmax, Km, Kcat

Competitive Inhibition and non-competitive Inhibition

Glycolysis and the catabolism of hexoses. Regulation of Glycolysis

Fate of pyruvate in aerobic and anaerobic conditions

Alcoholic fermentation

Regulation of carbohydrate catabolism. Secondary pathways of glucose oxidation

Use of disaccharides, galactose, fructose glycogenosynthesis

Regulation of glycogenosynthesis (in muscle and liver). Glycogenolysis.

Regulation of Glycogenolysis and Gluconeogenesis

Pyruvate carboxylase: mechanism of action. Complex of Pyruvate dehydrogenase

The Krebs cycle

The flow of mitochondrial electrons;

The electron transport chain;

The synthesis of ATP is coupled to the flow of electrons in the respiratory chain;

Second part

Structure and physiological role of fatty acids;

Structure, digestion and absorption of triglycerides;

Classification and structure of lipoproteins;

Mobilization and transport of fatty acids;

Transaminase and urea cycle

Biochemistry of muscle contraction

Bridging Courses

Physics / Chemistry and propaedeutics of biochemistry

Learning Achievements (Dublin Descriptors)

In agreement with the Dublin Descriptors, the student must demonstrate:

- To have achieved a knowledge and understanding of biochemistry that allows him to set up the discussion in a coherent and logical way, and to be able to make connections between the different topics;

-  To show the ability to use knowledge and concepts to solve problems related to the biochemistry of exercise;

-  To expose one's own knowledge with specific language and scientific vocabulary;

Teaching Material

The teaching material prepared by the lecturer in addition to recommended textbooks (such as for instance slides, lecture notes, exercises, bibliography) and communications from the lecturer specific to the course can be found inside the Moodle platform › blended.uniurb.it

Supporting Activities

There are no supporting activities to teaching


Didactics, Attendance, Course Books and Assessment

Didactics

Frontal lessons

Attendance

There is no compulsory attendance

Course books

D.L.  Nelson, M.M. Cox. I principi di biochimica di Lehninger. Zanichelli

L. Strayer. Biochimica. Zanichelli

A.L. Lehninger. Biochimica. Zanichelli

D. Voet, J.G. Voet, C.W. Pratt – Fondamenti di biochimica. Zanichelli

Assessment

Expected learning outcomes will be evaluated through an oral interview that will take into account the knowledge and deepening of the topics of the program, the ability to link the different aspects of the metabolism in conditions of rest and in response to physical exercise. In more ditails, the oral interview will take into account: knowledge and understanding skills (6, excellent, 5, good, 4 sufficient, 3 insufficient); Consciousness and understanding ability applied (6, excellent, 5, good, 4 sufficient, 3 insufficient); judgment autonomy (6, excellent, 5, good, 4 sufficient, 3 insufficient); communicative abilities (6, excellent, 5, good, 4 sufficient, 3 insufficient); ability to learn (6, excellent, 5, good, 4 sufficient, 3 insufficient).

The oral test is expressed in thirty.

Additional Information for Non-Attending Students

Didactics

Non-attending students are invited to consult the educational material uploaded on Moodle (slides discussed in class, examples of educational research, types of detection tools, etc.) through which it will be possible to study the books indicated in the section "program information".

Attendance

There is no compulsory attendance

Course books

D.L.  Nelson, M.M. Cox. I principi di biochimica di Lehninger. Zanichelli

L. Strayer. Biochimica. Zanichelli

A.L. Lehninger. Biochimica. Zanichelli

D. Voet, J.G. Voet, C.W. Pratt – Fondamenti di biochimica. Zanichelli

Assessment

Expected learning outcomes will be evaluated through an oral interview that will take into account the knowledge and deepening of the topics of the program, the ability to link the different aspects of the metabolism in conditions of rest and in response to physical exercise. In more ditails, the oral interview will take into account: knowledge and understanding skills (6, excellent, 5, good, 4 sufficient, 3 insufficient); Consciousness and understanding ability applied (6, excellent, 5, good, 4 sufficient, 3 insufficient); judgment autonomy (6, excellent, 5, good, 4 sufficient, 3 insufficient); communicative abilities (6, excellent, 5, good, 4 sufficient, 3 insufficient); ability to learn (6, excellent, 5, good, 4 sufficient, 3 insufficient).

The oral test is expressed in thirty.

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