BIOCHEMISTRY
BIOCHIMICA
| A.Y. | Credits |
|---|---|
| 2019/2020 | 8 |
| Lecturer | Office hours for students | |
|---|---|---|
| Vilberto Stocchi |
Assigned to the Degree Course
| Date | Time | Classroom / Location |
|---|
| Date | Time | Classroom / Location |
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Learning Objectives
The course aims to provide students with basic knowledge on fundamental processes of the biochemical mechanisms that regulate cellular metabolic activities with particular attention to energy metabolism and to the molecular basis of adaptation to physical exercise.
Program
The course will address the following topics in the order below:
First part
Principles of bioenergetics and thermodynamics. Cells and sources of free energy.
Paired reactions and free energy variations The transfer of phosphoric groups and ATP.
Free energy standard of phosphorylated compounds (Fosfoenolpyruvate, 1,3 diphosphoglycerate, Phosphocreatine) and thioesters (Acetyl Coenzyme A)
ATP provides energy by group transfer, not by simple hydrolysis
Enzymes
Classification of enzymes. How enzymes work: enzymatic kinetics
Michaelis's equation - Menten Vmax, Km, Kcat
Competitive Inhibition and non-competitive Inhibition
Glycolysis and the catabolism of hexoses. Regulation of Glycolysis
Fate of pyruvate in aerobic and anaerobic conditions
Alcoholic fermentation
Regulation of carbohydrate catabolism. Secondary pathways of glucose oxidation
Use of disaccharides, galactose, fructose glycogenosynthesis
Regulation of glycogenosynthesis (in muscle and liver). Glycogenolysis.
Regulation of Glycogenolysis and Gluconeogenesis
Pyruvate carboxylase: mechanism of action. Complex of Pyruvate dehydrogenase
The Krebs cycle
The flow of mitochondrial electrons;
The electron transport chain;
The synthesis of ATP is coupled to the flow of electrons in the respiratory chain;
Second part
Structure and physiological role of fatty acids;
Structure, digestion and absorption of triglycerides;
Classification and structure of lipoproteins;
Mobilization and transport of fatty acids;
Transaminase and urea cycle
Biochemistry of muscle contraction
Teaching Material
The teaching material prepared by the lecturer in addition to recommended textbooks (such as for instance slides, lecture notes, exercises, bibliography) and communications from the lecturer specific to the course can be found inside the Moodle platform › blended.uniurb.it
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