CLINICAL PHARMACOLOGY
FARMACOLOGIA CLINICA
| A.Y. | Credits |
|---|---|
| 2022/2023 | 6 |
| Lecturer | Office hours for students | |
|---|---|---|
| Andrea Guidarelli | Any working day (it is advisable to make an appointment by email at the address given, or by telephone at +39 0722 303524) |
| Teaching in foreign languages |
|---|
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Course with optional materials in a foreign language
English
Spanish
This course is entirely taught in Italian. Study materials can be provided in the foreign language and the final exam can be taken in the foreign language. |
Assigned to the Degree Course
| Date | Time | Classroom / Location |
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| Date | Time | Classroom / Location |
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Learning Objectives
The aim of the course is to provide knowledge about routes of administration, metabolism, distribution, and elimination of biotechnological and synthetic drugs as well as the basic concepts of their therapeutic and the related toxic effects.
Program
Definition of drug (biotechnological and syntetic), medicine and poison.
Pharmacokinetics of biotechnological and synthetic drugs: Physicochemical factors in transfer of drugs across membranes, absorption, bioavailability, and routes of administration. Distribution of drugs. Biotransformation of drugs. Excretion of drugs.
Pharmacodynamics of biotechnological and synthetic drugs: Mechanisms of drug action, factors that modify the action of biotechnological and synthetic drugs (age, pathological states, drug interactions, tolerance) and the related toxic effects.
Bridging Courses
Knowledge of Molecular Biology and Physiology.
Learning Achievements (Dublin Descriptors)
At the end of the course the student possesses the basic knowledge of the mechanisms regulating the kinetics of biotechnological and synthetic drug in the body as well as interactions with the biological targets responsible for its activity. In particular, the student: - knows the essential elements of pharmacokinetics, - understands the basics of biotransformation, - knows how to interact with biological targets.
The topics discussed will then provide the student with basic knowledge of the relationships between biotechnological and synthetic drugs and molecular mechanisms of cellular metabolism. In addition, the major issues related to possible interactions between drugs.
Knowledge and understanding. At the end of the course, the student will have the skills to understand of the concepts of pharmacokinetics and pharmacodynamics and the notions relating to the molecular mechanisms underlying the action of biotechnological and synthetic drugs.
Ability to apply knowledge and understanding. At the end of the course, the student must be able to understand how the therapeutic response of biotechnological and synthetic drugs is conditioned by their pharmacokinetics and pharmacodynamics characteristics.
Judgment. At the end of the course, the student must be able to analyse and then predict therapeutic alternatives based on the pharmacokinetics pharmacodynamics parameters of biotechnological and synthetic drugs.
Communication skills. At the end of the course, the student must demonstrate that he/she is able to expose the notions referred in section knowledge and understanding through a scientific and critical lexicon.
Learning skills. At the end of the course, the student must demonstrate that he is able to independently know and learn the pharmacokinetics and pharmacodynamics of biotechnological and synthetic drugs that modulate the different pharmacological responses. Furthermore, will be able to build up his scientific knowledge in a critical way, using not only the study material provided by the professor but also dedicating himself to in-depth studies.
Teaching Material
The teaching material prepared by the lecturer in addition to recommended textbooks (such as for instance slides, lecture notes, exercises, bibliography) and communications from the lecturer specific to the course can be found inside the Moodle platform › blended.uniurb.it
Supporting Activities
Frontal lessons (MS Power Point).
The teaching material and the teacher's specific communications can be found, together with other support activities, within the Moodle platform> blended.uniurb.it
Teaching, Attendance, Course Books and Assessment
- Teaching
Frontal lessons (MS Power Point).
- Innovative teaching methods
Flipped classroom. Some lessons will involve the distribution of pdf of scientific articles in english that students will have to
read before the lesson.
- Attendance
Knowledge regarding biological subjects (anatomy, biochemistry and physiology).
Class attendance is not mandatory but is strongly recommended on a regular basis to encourage both classroom interaction and the acquisition of knowledge and skills.
- Course books
Farmaci biotecnologici - Aspetti farmacologici e clinici. (Vegeto - Maggi - Minghetti). Casa Editrice Ambrosiana
Goodman and Gilman - Le basi farmacologiche della terapia (2019).
- Assessment
The course is examined through oral examination with questions to evaluate the students' knowledge about the mechanisms of basic principles of pharmacology; address the issues related to potential interactions between drugs, dietary supplements and food. The final mark (out of 30) will be based on the skill of the students to answer properly to the questions.
- Disabilità e DSA
Le studentesse e gli studenti che hanno registrato la certificazione di disabilità o la certificazione di DSA presso l'Ufficio Inclusione e diritto allo studio, possono chiedere di utilizzare le mappe concettuali (per parole chiave) durante la prova di esame.
A tal fine, è necessario inviare le mappe, due settimane prima dell’appello di esame, alla o al docente del corso, che ne verificherà la coerenza con le indicazioni delle linee guida di ateneo e potrà chiederne la modifica.
Additional Information for Non-Attending Students
- Teaching
Non-attending students are encouraged to submit the Moodle teaching material (slide discussed in the lesson) through which you can deepen the study of the volumes indicated in the "Study texts" section.
- Attendance
Knowledge regarding biological subjects (anatomy, biochemistry and physiology)..
- Course books
Farmaci biotecnologici - Aspetti farmacologici e clinici. (Vegeto - Maggi - Minghetti). Casa Editrice Ambrosiana
Goodman and Gilman - Le basi farmacologiche della terapia (2019).
- Assessment
The course is examined through oral examination with questions to evaluate the students' knowledge about the mechanisms of basic principles of pharmacology; address the issues related to potential interactions between drugs, dietary supplements and food. The final mark (out of 30) will be based on the skill of the students to answer properly to the questions.
- Disabilità e DSA
Le studentesse e gli studenti che hanno registrato la certificazione di disabilità o la certificazione di DSA presso l'Ufficio Inclusione e diritto allo studio, possono chiedere di utilizzare le mappe concettuali (per parole chiave) durante la prova di esame.
A tal fine, è necessario inviare le mappe, due settimane prima dell’appello di esame, alla o al docente del corso, che ne verificherà la coerenza con le indicazioni delle linee guida di ateneo e potrà chiederne la modifica.
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