Università degli Studi di Urbino Carlo Bo / Portale Web di Ateneo


A.Y. Credits
2022/2023 8
Lecturer Email Office hours for students
Mirco Fanelli
Teaching in foreign languages
Course with optional materials in a foreign language English
This course is entirely taught in Italian. Study materials can be provided in the foreign language and the final exam can be taken in the foreign language.

Assigned to the Degree Course

Biotechnology (L-2)
Date Time Classroom / Location
Date Time Classroom / Location

Learning Objectives

The course aims to provide students with the basic knowledge of human disease and to provide an overview of modern cellular and molecular immunology seeking to understand the mechanisms that regulate the normal, but also the "abnormal", functioning of immune system. It will be taken into account also the techniques used for the study and diagnosis of disease patterns examined.


1. Cellular injury
1.1. Cellular injury
1.1 Molecular mechanisms of cancer
1.2 Reversible injury vs irreversible injury
1.3 Free radicals and chemical injury
1.4 Ischemia and reperfusion injury
2. Cellular adaptation
2.1 Atrophy, ipertrophy, hyperplasia e metaplasia
3. Cell death
3.1 Apoptosis
3.2 Necrosis
4. Inflammation
4.1 Acute inflammation: mechanism, phagocytosis and degranulation
4.2 Chemical mediators of inflammation
4.3 Chronic inflammation: mechanism
4.4 Repair processes
4.5 Granulomatous inflammation
5. Neoplastic diseases
5.1 Definition, classification and general features
5.2 Differentation and anaplasia
5.3 Tumour progression
5.4 Environmental factors
5.5 Genetic lesions of cancer: proto-oncogenes, oncosuppressors and oncogenes
5.6 Cell cycle regulation and cancer
5.7 Acute Promyelocytic Leukaemia - APL
6. Immune system
6.1 General features
6.2 Immunity: natural vs acquierd
6.3 Immunity: active vs passive
6.4 Humoral theory and cellular theory of the immune response
6.5 Cells of the immune system
6.6 Toll-like receptors (from Drosophila to human)
6.7 Major histocompatibility complex (MHC)
6.8 T cell receptor (TCR)
6.9 Immunological tolerance
7. Hypersensitivity diseases (or reactions)

Bridging Courses


Learning Achievements (Dublin Descriptors)

Knowledge and understanding - Acquisition of the tools to understand the mechanisms of disease. Ability to use the language of their specific discipline.

Applying knowledge and understanding - Ability to recognize and apply the cognitive tools and the rigorous approach of the Pathology as rational of any activity related directly and indirectly to health protection.

Indipendence of judgment - Being able to learn and independently evaluate the results of investigations on the pathogenesis and diagnosis of diseases

Communicative skills ?- Ability to explain, in a simple, immediate and exhaustive manner the acquired knowledge and to know how to interface with future professional roles (researchers, students, health-operative).

Learning ability - Upgrade capabilities through consultation of the scientific literatue of the discipline. Ability to participate, using the knowledge gained in the course, the continuous updating initiatives in the professional field.

Teaching Material

The teaching material prepared by the lecturer in addition to recommended textbooks (such as for instance slides, lecture notes, exercises, bibliography) and communications from the lecturer specific to the course can be found inside the Moodle platform › blended.uniurb.it

Supporting Activities


Teaching, Attendance, Course Books and Assessment




No obligation

Course books

- Pontieri, Russo, Frati - Patologia Generale - PICCIN
- Robbins e Cotran - Le basi patologiche delle malattie - ELSEVIER
- Abbas- Le basi dell'Immunologia - MASSON -


oral examination

Additional Information for Non-Attending Students





Course books

- Pontieri, Russo, Frati - Patologia Generale - PICCIN
- Robbins e Cotran - Le basi patologiche delle malattie - ELSEVIER 
- Abbas- Le basi dell'Immunologia - MASSON -


Oral examination



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Università degli Studi di Urbino Carlo Bo
Via Aurelio Saffi, 2 – 61029 Urbino PU – IT
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