## FUNDAMENTALS OF ORGANIC AND PHYSICAL CHEMISTRY FONDAMENTI DI CHIMICA ORGANICA E DI CHIMICA FISICA

A.Y. Credits
2023/2024 3
Lecturer Email Office hours for students
Luca Giorgi Friday 9 -12 h on-line. Please send an e-mail for appointment at luca.giorgi@uniurb.it or using the Forum present in Blendede Learning.
Teaching in foreign languages
Course with optional materials in a foreign language English
This course is entirely taught in Italian. Study materials can be provided in the foreign language and the final exam can be taken in the foreign language.

### Assigned to the Degree Course

Industrial Pharmacy (LM-13)
Curriculum: PERCORSO COMUNE
Date Time Classroom / Location
Date Time Classroom / Location

### Learning Objectives

Students will acquire the fundamental knowledge on Phisical Chemistry with particular regard towards chemical equilibria and kynetics. He also will learn how to solve practical and numerical problems.

### Program

1) Therodynamics: definition of standard-state, entalpy, enthropy and free energy of reaction, Hess law

2) Chemical equilibrium:correlation with the thermodynamic functions, temperature and pressure effect

3) Chemical kynetic: definition of reaction rate, kynetic equations, kynetic constant, reaction order, integration of kynetic first ad second order equations, Arrhenius equation, activation anargy

4) Raction mechemisms: reaction coordinate, mycroscopic reversibility law, Hammond postulate, Bell-Evans-Polanyi principle, kynetic and thermodynamic control of reactions, Curtin-Hammett principle, reactivity-selectivity principle

5) Kynetic: series and parallel reactions, stationary state model, enxymatic cathalisis, pre-equilibrium model, transition entalpy, entropy and free energy

6) Free energy linear correlations: Hammett equation, Yukawa-Tsuno byparametric  equations, steric effectsi (Taft equation)

7) Solvent effect: solvation energy, dipole moment, dielectric constant, ionizer power, acid-base properties, donating and accepting number (DN, AN)

8) Cathalysis: general and specific acid-base cathalysis, metal cathalysis, organic cathalysis, tphase transfert

### Bridging Courses

For a better comprehension of the arguments trated in the course, studend need to have solid knowledge about general chemistry, mathematics and physycs.

### Learning Achievements (Dublin Descriptors)

• D1 - Knowledge and understanding ability. Students will be able to describe the foundamental principles of thermodynamics, kynetics and chemical structure of atoms and molecules, and to relate these topics with principles of general chemistry learned in the first semester. Moreover it must learn the mathematical techniques useful to solve pratical problems. This ability will be ascertained in an oral examination.
• D2 - Application of knowledge and understanding. Students will be able to use the physical chemistry laws with the aim to explain the behaviour of a chemical substance in a complex system, and in particular they will be apble to apply these principle in the pharmaceutical field (distribution, binding, clearance, self-life, enzimatc reactions of drugs). The achievement of these abilities will be tested through an oral examination.
• D3 - Judgement autonomy. Student will focus their attention on the phisycal chemical models suitable for solve a real problem o to interpret a series of experimental data, and it will be able to choice the model that better fit with the problem. The achievement of these abilities will be tested through the written examination and oral questions aimed at estimate them.
• D4 - Communication ability. Students will be able to clearly describe the physical-chemical phenomena learned in the course with appropriate language and examples.
• D5 - Learnning ability. Students will be able to grow autonomously and critically their scientific knowledges by using the teaching material provided by the teacher and any other book or scientific article provided by themselves. These abilities will be stimulated by the teacher proposing and resolving numeric problems.

### Teaching Material

The teaching material prepared by the lecturer in addition to recommended textbooks (such as for instance slides, lecture notes, exercises, bibliography) and communications from the lecturer specific to the course can be found inside the Moodle platform › blended.uniurb.it

### Supporting Activities

Numerical exercices in classroom

### Teaching, Attendance, Course Books and Assessment

Teaching

Frontal lessons

Attendance

Not mandatory but strongly encouraged

Course books

P.W. Atkins, J. De Paula. Elements of Physical Chemistry. 7th edition (Oxford, 2016), ISBN: 9780198727873

Assessment

The final exam is aimed at verifying the acquired knowledge and skills. It consists of a written test of two hours, followed by an oral exam.

Disabilità e DSA

Le studentesse e gli studenti che hanno registrato la certificazione di disabilità o la certificazione di DSA presso l'Ufficio Inclusione e diritto allo studio, possono chiedere di utilizzare le mappe concettuali (per parole chiave) durante la prova di esame.

A tal fine, è necessario inviare le mappe, due settimane prima dell’appello di esame, alla o al docente del corso, che ne verificherà la coerenza con le indicazioni delle linee guida di ateneo e potrà chiederne la modifica.

### Additional Information for Non-Attending Students

Teaching

All didactic material can be found inside the Moodle platform › blended.uniurb.it

Attendance

Not mandatory

Course books

P.W. Atkins, J. De Paula. Elements of Physical Chemistry. 7th edition (Oxford, 2016), ISBN: 9780198727873

Assessment

The final exam is aimed at verifying the acquired knowledge and skills. It consists of a written test of two hours, followed by an oral exam.

Disabilità e DSA

Le studentesse e gli studenti che hanno registrato la certificazione di disabilità o la certificazione di DSA presso l'Ufficio Inclusione e diritto allo studio, possono chiedere di utilizzare le mappe concettuali (per parole chiave) durante la prova di esame.

A tal fine, è necessario inviare le mappe, due settimane prima dell’appello di esame, alla o al docente del corso, che ne verificherà la coerenza con le indicazioni delle linee guida di ateneo e potrà chiederne la modifica.

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