MOLECULAR MECHANISM OF METABOLIC DISEASES
MECCANISMI MOLECOLARI DELLE MALATTIE METABOLICHE
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Course with optional materials in a foreign language
This course is entirely taught in Italian. Study materials can be provided in the foreign language and the final exam can be taken in the foreign language.
Assigned to the Degree Course
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The course will provide the molecular basis of diseases that most frequently affect the adult population of the industrialized societies . It will also provide guidance regarding prevention of such diseases through appropriate physical activity and healthy eating habits.
The course will address the following topics in the order below. Etiologic agents.
Elements of environmental disease.
Mechanisms of cellular damage. Cell death: apoptosis and necrosis. Innate immunity: cells, receptors and mechanisms of action.
Acute and chronic inflammation, chemical mediators of inflammation, systemic manifestations of inflammation.
Acquired immunity: lymphocytes and cellular basis of adaptive immunity, B cells and antibodies, the generation of antibody diversity. T cells and MHC proteins.
Relations between metabolic organs in various nutritional and hormonal states .
Diabetes mellitus: diabetes type 1 and 2; Insulin: structure, function and mechanism of action; Biochemical alterations of the tissues resulting hyperglycemia.
Obesity: white and brown adipose tissue;
biochemical composition of adipocyte; Termogenesis, Adipose tissue as secretory organ.
Synthesis, structure and function of LDL and HDL.
Atherosclerosis as chronic inflammatory response
Cancer: Molecular basis of the behavior of neoplastic cells
Learning Achievements (Dublin Descriptors)
Students have to prove the acquirement of the basic knowledge of defensive mechanisms put in place by human organism in response to harmful stimuli of various nature. Students have to prove the understanding of the concepts and have the ability to transfer such acquisitions in practice of patients's rehabilitation.It must show the possession of communication skills , using a correct terminology and they must be able to interface with other professional figures working in healthcare. Students must show the possession of the ability to use knowledges and concepts in the programming of customized programs for functional rehabilitation of patients affected by different clinical conditions.
The teaching material prepared by the lecturer in addition to recommended textbooks (such as for instance slides, lecture notes, exercises, bibliography) and communications from the lecturer specific to the course can be found inside the Moodle platform › blended.uniurb.it
Didactics, Attendance, Course Books and Assessment
- Course books
Patologia generale Pontieri , Russo, Frati Ed. Piccin Nuova Libraria 2010 Introduction to the Course (Chapter 1). Elements of environmental diseases (Chapter 4). Cell death : apoptosis and necrosis (chapter 10) Innate immunity : cells , receptors and mechanisms of action Acute and chronic inflammation , chemical mediators of inflammation , systemic manifestations of inflammation (chapter 15), diabetes (Chapter .52), obesity (Chapter 53), atherosclerosis (Chapter 45 and Chapter 55)
Immunologia Coico, Sunshine and Benjamini Edises 2005 Acquired immunity : lymphocytes and cellular basis of adaptive immunity , B cells and antibodies , the generation of antibody diversity. T cells, MHC proteins, and lymphocyte activation .
Other additional material will be available in the platform Moodle
Oral interview to evaluate 1) knowledge and understanding skills (6, excellent, 5, good, 4 sufficient, 3 insufficient); 2) applying knowledge and understanding ability (6, excellent, 5, good, 4 sufficient, 3 insufficient);3)making judgements (6, excellent, 5, good, 4 sufficient, 3 insufficient); 4) communication skills (6, excellent, 5, good, 4 sufficient, 3 insufficient); 5) learning skills (6, excellent, 5, good, 4 sufficient, 3 insufficient)
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