The course aims to provide the biochemical and molecular foundations of diseases that most frequently affect the adult population in Western countries. It will also offer guidance on the prevention of such diseases through adequate physical activity and a healthy diet. The course provides the knowledge and terms necessary to interact with different professional figures working in the healthcare field 

The course will address the following topics in the order below. 

Definition of  homeostasis

Etiological agents

Mechanisms of cellular damage. Cell death: apoptosis and necrosis.

Innate immunity: cells, receptors and mechanisms of action.

Inflammation

Acquired immunity: lymphocytes and cellular basis of adaptive immunity, B cells and antibodies, MHC proteins,  cytotoxic T lymphocytes and helper T lymphocytes

Relations between metabolic organs in various nutritional and hormonal  states .

Diabetes mellitus:  diabetes type 1 and 2; Insulin: structure, function and mechanism of action; molecular mechanisms of insulin resistance.

Obesity and energetic homeostasis.  Adipokines

Metaflammation

Synthesis, structure and function of lipoproteins

Atherosclerosis as chronic inflammatory response

Cancer: molecular basis of the behavior of neoplastic cells. Oncoprotective role of physical exercise

Intestinal microbiota in health and oncology

Anti-inflammatory role of physical exercise and diet

none

Knowledge and understanding. The student must demonstrate that the basic knowledge regarding the defense mechanisms adopted by the human organism in response to various harmful stimuli are acquired. The student must demonstrate to have understood the molecular mechanisms underlying the establishment of metabolic diseases such as obesity, type 2 diabetes, metabolic syndrome and atherosclerosis, as well as tumors.

Applied knowledge and understanding. The student must demonstrate an understanding of the concepts and  the ability to transfer the acquired concepts into the practical activity 

Making judgements. The student must demonstrate the ability to use knowledge and concepts in the planning of personalized programs of functional re-education considering the characteristics and clinical condition of the patient.

Communication skills. The student must show the possession of the communication skills, using the correct terminology and must be able to interface with other professional figures operating in the health sector

Learning skills. The student must be able to build his path of scientific growth in a critical and autonomous way, being able to correctly use the study material recommended by the teacher as well as the in-depth material that he can procure himself. These skills will be stimulated by the teacher who will propose insights on topics of interest

The teaching material prepared by the lecturer in addition to recommended textbooks (such as for instance slides, lecture notes, exercises, bibliography) and communications from the lecturer specific to the course can be found inside the Moodle platform › blended.uniurb.it

not foreseen

Teaching

front lessons

Innovative teaching methods

Flipped classroom

Attendance

It is not scheduled obligation to frequency; it is recommended

Course books

Patologia generale e fisiopatologia generale   Pontieri , Russo, Frati V Ed. Piccin Nuova Libraria  2015  Cell death : apoptosis and necrosis (chapter 10) Innate immunity : cells , receptors and mechanisms of action Acute and chronic inflammation , chemical mediators of inflammation , systemic manifestations of inflammation (chapter 15),  diabetes (Chapter 54), obesity (Chapter 55), lipoprotein metabolism and atherosclerosis (Chapter 46 and  Chapter 57)  

Immunologia  Coico, Sunshine and Benjamini Edises 2005 Acquired immunity : lymphocytes and cellular basis of adaptive immunity , B cells and antibodies , the generation of antibody diversity. T cells, MHC proteins, and lymphocyte activation . 

Other additional material will be available in the platform Moodle 

Assessment

Expected learning outcomes will be assessed through an oral interview on three main topics. The final assessment will be made on the basis of: knowledge and understanding (6, very good, 5, good, 4 sufficient, 3 insufficient); applied awareness and understanding (6, very good, 5, good, 4 sufficient, 3 insufficient); autonomy of judgement (6, very good, 5, good, 4 sufficient, 3 insufficient); communication skills (6, very good, 5, good, 4 sufficient, 3 insufficient); learning ability (6, very good, 5, good, 4 sufficient, 3 insufficient).

The oral test is expressed in thirtieths.

Disability and Specific Learning Disorders (SLD)

Students who have registered their disability certification or SLD certification with the Inclusion and Right to Study Office can request to use conceptual maps (for keywords) during exams.

To this end, it is necessary to send the maps, two weeks before the exam date, to the course instructor, who will verify their compliance with the university guidelines and may request modifications.

Teaching

The same of attending students

Course books

Patologia generale e fisiopatologia generale   Pontieri , Russo, Frati V Ed. Piccin Nuova Libraria  2015  Cell death : apoptosis and necrosis (chapter 10) Innate immunity : cells , receptors and mechanisms of action Acute and chronic inflammation , chemical mediators of inflammation , systemic manifestations of inflammation (chapter 15),  diabetes (Chapter 54), obesity (Chapter 55), lipoprotein metabolism and atherosclerosis (Chapter 46 and  Chapter 57)  

Immunologia  Coico, Sunshine and Benjamini Edises 2005 Acquired immunity : lymphocytes and cellular basis of adaptive immunity , B cells and antibodies , the generation of antibody diversity. T cells, MHC proteins, and lymphocyte activation . 

Other additional material will be available in the platform Moodle 

Assessment

Expected learning outcomes will be evaluated through an oral interview that will take into account: knowledge and understanding skills (6, excellent, 5, good, 4 sufficient, 3 insufficient); Consciousness and understanding ability applied (6, excellent, 5, good, 4 sufficient, 3 insufficient); judgment autonomy (6, excellent, 5, good, 4 sufficient, 3 insufficient); communicative abilities (6, excellent, 5, good, 4 sufficient, 3 insufficient); ability to learn (6, excellent, 5, good, 4 sufficient, 3 insufficient).

The oral test is expressed in thirty.

Disability and Specific Learning Disorders (SLD)

Students who have registered their disability certification or SLD certification with the Inclusion and Right to Study Office can request to use conceptual maps (for keywords) during exams.

To this end, it is necessary to send the maps, two weeks before the exam date, to the course instructor, who will verify their compliance with the university guidelines and may request modifications.