Matteo Micucci / Ricercatore Legge 240/10 a tempo determinato

Matteo Micucci (Cesena, 1983) svolge attività di ricerca nel settore scientifico disciplinare chim10 (Chimica degli Aliment). Ha studiato “Farmacia e Farmacia Industriale” presso l’Università di Bologna, laureandosi  con 110/110 e lode discutendo una tesi sperimentale dal titolo “Aspetti chimico-farmaceutici e attività spasmolitica di alcuni principi attivi contenuti nella Solenostemma Argel”
Nella stessa Università, ha conseguito il Dottorato di Ricerca Europeo in Scienze Farmaceutiche, in data 20/04/2012.

Ha svolto attività di Ricerca presso il Laboratorio di Ricerca coordinato dal Dr. Randolph Arroo, De Montfort University (Leicester, UK) dedicandosi all'acquisizione di tecniche di estrazione e isolamento di principi attivi da matrici vegetali. 

La sua produzione scientifica è testimoniata da numerose pubblicazioni su autorevoli riviste di rilievo internazionale, nonchè dalle sue relazioni in congressi nazionali ed internazionali.

1. Das G, Budriesi R, Shin HS, Urso F, Bose S, Banerjee S, Rodriguez-Torres MDP, Mattioli LB, Patra JK, Micucci M. Nutraceuticals, a Bridge Between Past and Future: Focus on Mushrooms Biological Activities and Myco-Chemistry. Mini Rev Med Chem. 2022 Jun 22. doi: 10.2174/1389557522666220622104845.
2. Curci F, Corbo F, Clodoveo ML, Salvagno L, Rosato A, Corazza I, Budriesi R, Micucci M, Mattioli LB. Polyphenols from Olive-Mill Wastewater and Biological Activity: Focus on Irritable Bowel Syndrome. Nutrients. 2022; 14(6): 1264.
3. Mattioli LB, Frosini M, Amoroso R, Maccallini C, Chiano E, Aldini R, Urso F, Corazza I, Micucci M, Budriesi R. Olea europea L. Leaves and Hibiscus sabdariffa L. Petals Extracts: Herbal Mix from Cardiovascular Network Target to Gut Motility Dysfunction Application. Nutrients. 2022 Jan 21;14(3):463.
4. Magurano F, Sucameli M, Picone P, Micucci M, Baggieri M, Marchi A, Bucci P, Gioacchini S, Catinella G, Borgonovo G, Dallavalle S, Nuzzo D, Pinto A. Antioxidant Activity of Citrus Limonoids and Investigation of Their Virucidal Potential against SARS-CoV-2 in Cellular Models. Antioxidants (Basel). 2021; 10(11): 1794.
5. Chiaino E, Stella R, Peggion C, Micucci M, Budriesi R, Mattioli LB, Marzetti C, Pessina F, Valoti M, Frosini M. Acacia catechu Willd. Extract Protects Neuronal Cells from Oxidative Stress-Induced Damage. Antioxidants (Basel). 2021; 11(1):81.
6. Chiaino E, Micucci M, Budriesi R, Mattioli LB, Marzetti C, Corsini M, Frosini M. Hibiscus Flower and Olive Leaf Extracts Activate Apoptosis in SH-SY5Y Cells. Antioxidants (Basel). 2021; 10(12): 1962.
7. Fiorino S, Tateo F, Biase D, Gallo CG, Orlandi PE, Corazza I, Budriesi R, Micucci M, Visani M, Loggi E, Hong W, Pica R, Lari F, Zippi M. SARS-CoV-2: lessons from both the history of medicine and from the biological behavior of other well-known viruses. Future Microbiol. 2021 Sep 1:10.2217/fmb-2021-0064.
8. Zippi M, Fiorino S, Budriesi R, Micucci M, Corazza I, Pica R, de Biase D, Gallo CG, Hong W. Paradoxical relationship between proton pump inhibitors and COVID-19: A systematic review and meta-analysis. World J Clin Cases. 2021 Apr 26;9(12):2763-2777.
9. Mallamaci R, Budriesi R, Clodoveo ML, Biotti G, Micucci M, Ragusa A, Curci F, Muraglia M, Corbo F, Franchini C. Olive Tree in Circular Economy as a Source of Secondary Metabolites Active for Human and Animal Health Beyond Oxidative Stress and Inflammation. Molecules. 2021; 26(4): 1072.
10. Carocci A, Roselli M, Budriesi R, Micucci M, Cavalluzzi MM, Milani G, Catalano A, De Palma A, Corbo F, Franchini C, Habtemariam S, Giovanni L. Synthesis and evaluation of voltage-gated sodium channel blocking pyrroline derivatives endowed with both antiarrhythmic and antioxidant activities. ChemMedChem. 2021; 16(3): 578-588.
11. Cavalluzzi MM, Budriesi R, De Salvia MA, Quintieri L, Piarulli M, Milani G, Gualdani R, Micucci M, Corazza I, Rosato A, Viale M, Caputo L, Franchini C, Lentini G. Lubeluzole: from anti-ischemic drug to preclinical antidiarrheal studies. Pharmacol Rep. 2021; 73(1): 172-184.
12. Micucci M, Budriesi R, Aldini R, Fato R, Bergamini C, Vivarelli F, Canistro D, Bolchi C, Chiarini A, Rizzardi N, Pallavicini M, Frosini M, Angeletti A. Castanea sativa Mill. bark extract cardiovascular effects in a rat model of high-fat diet. Phytother Res. 2021; 35(4): 2145-2156
13. Zeka K, Marrazzo P, Micucci M, Ruparelia KC, Arroo RRJ, Macchiarelli G, Annarita Nottola S, Continenza MA, Chiarini A, Angeloni C, Hrelia S, Budriesi R. Activity of Antioxidants from Crocus sativus L. Petals: Potential Preventive Effects towards Cardiovascular System. Antioxidants (Basel). 2020; 9(11): 1102
14. Micucci M, Protti M, Aldini R, Frosini M, Corazza I, Marzetti C, Mattioli LB, Tocci G, Chiarini A, Mercolini L, Budriesi R. Thymus vulgaris L. Essential Oil Solid Formulation: Chemical Profile and Spasmolytic and Antimicrobial Effects. Biomolecules. 2020; 10(6): 860
15. Chiaino E, Micucci M, Cosconati S, Novellino E, Budriesi R, Chiarini A, Frosini M. Olive Leaves and Hibiscus Flowers Extracts-Based Preparation Protect Brain from Oxidative Stress-Induced Injury. Antioxidants (Basel). 2020; 9(9): E806
16. Chiaino E, Micucci M, Durante M, Budriesi R, Gotti R, Marzetti C, Chiarini A, Frosini M., Apoptotic-Induced Effects of Acacia Catechu Willd. Extract in Human Colon Cancer Cells, Int J Mol Sci. 2020; 21(6). pii: E2102.
17. Matteo Micucci, Maurizio Viale, Alberto Chiarini, Domenico Spinelli, Maria Frosini, Cinzia Tavani, Massimo Maccagno, Lara Bianchi, Rosaria Gangemi, and Roberta Budriesi, 3-Aryl-4-nitrobenzothiochromans S,S-dioxide: From Calcium-Channel Modulators Properties to Multidrug-Resistance Reverting Activity, Molecules. 2020, 25(5): 1056
18. Micucci M, Bolchi C, Budriesi R, Cevenini M, Maroni L, Capozza S, Chiarini A, Pallavicini M, Angeletti A, Antihypertensive phytocomplexes of proven efficacy and well-established use: Mode of action and individual characterization of the active constituents, Phytochemistry. 2020; 170: 112222
19. Farzaei MH, Singh AK, Kumar R, Croley CR, Pandey AK, Coy-Barrera E, Kumar Patra J, Das G, Kerry RG, Annunziata G, Tenore GC, Khan H, Micucci M, Budriesi R, Momtaz S, Nabavi SM, Bishayee A., Targeting Inflammation by Flavonoids: Novel Therapeutic Strategy for Metabolic Disorders, Int J Mol Sci. 2019; 20(19). pii: E4957
20. Micucci M, Tarro G, Tumor Liberated Protein (TLP) as Potential Target for Immunotherapy Associated to Nutraceutical Supplements, Japan Journal of Medicine, 2019; 2(2): 344 - 346
21. Iaccarino N, Amato J, Pagano B, Di Porzio A, Micucci M, Bolelli L, Aldini R, Novellino E, Budriesi R, Randazzo A., Impact of phytosterols on liver and distal colon metabolome in experimental murine colitis model: an explorative study, J Enzyme Inhib Med Chem. 2019;34(1):1041-1050
22. Leoni A, Frosini M, Locatelli A, Micucci M, Carotenuto C, Durante M, Cosconati S, Budriesi R., 4-Imidazo[2,1-b]thiazole-1,4-DHPs and neuroprotection: preliminary study in hits searching, Eur J Med Chem. 2019; 169:89-102
23. Bisi A, Arribas RL, Micucci M, Budriesi R, Feoli A, Castellano S, Belluti F, Gobbi S, de Los Rios C, Rampa A., Polycyclic maleimide-based derivatives as first dual modulators of neuronal calcium channels and GSK-3β for Alzheimer's disease treatment, Eur J Med Chem., 2019; 163: 394-402
24. Matteo Micucci, Alberto Chiarini, Roberta Budriesi, Neutral/negative α1-AR antagonists and calcium channel blockers at comparison in functional tests on guinea-pig smooth muscle and myocardium, Pharmacol Rep. 2018 ;71(1):128-132
25. Bisi A, Micucci M, Gobbi S, Belluti F, Budriesi R, Rampa A., Cardiovascular Profile of Xanthone-Based 1,4 Dihydropyridines Bearing a Lidoflazine Pharmacophore Fragment, Molecules. 2018; 23 (12)
26. Santulli C, Brizi C, Durante M,  Micucci M, Budriesi R,  Chiarini A, Frosini M, Apoptotic-induced effects of castanea sativa bark extract in human SH-SY5Y neuroblastoma cells. Natural Product Communications, 2018,  13, 887-890
27. Budriesi R, Vivarelli F, Canistro D, Aldini R, Babot Marquillas C, Corazza I, Fato R, Cirillo S, Bergamini C, D'Errico A, Bolchi C, Cevenini M, Degiovanni A, Frosini M, Camarda L, Chiarini A, Micucci M., Liver and intestinal protective effects of Castanea sativa Mill. bark extract in high-fat diet rats, PLoS One. 2018; 13(8): e0201540
28. Leoni A, Budriesi R, Poli F, Lianza M, Graziadio A, Venturini A, Broccoli M, Micucci M, Ayurvedic preparation of Zingiber officinale Roscoe: effects on cardiac and on smooth muscle parameters, Nat Prod Res. 2017, 28:1-8
29. Micucci M, Gotti R, Corazza I, Tocci G, Chiarini A, De Giorgio M, Camarda L, Frosini M, Marzetti C, Cevenini M, Budriesi R., Newer Insights into the Antidiarrheal Effects of Acacia catechu Willd. Extract in Guinea Pig, J Med Food. 2017; 20(6): 592-600
30. Papa V, Ginocchietti L, Budriesi R, Micucci M, Costa R, Biondi R, Cevenini R, Chiarini A, Aldini R, Donati M, Pollini GM, Cenacchi  G, In vitro activity of a partially purified and characterized bark extract of Castanea sativa Mill . (ENC®) against Chlamydia spp, Ultrastructural Pathology, 2017, 1–7
31. Santulli C, Brizi C, Micucci M, Del Genio A, De Cristofaro A, Bracco F, Pepe GL, di Perna I, Budriesi R, Chiarini A, Frosini M., Castanea sativa Mill. Bark Extract Protects U-373 MG Cells and Rat Brain Slices Against Ischemia and Reperfusion Injury, J Cell Biochem., 2017; 118(4): 839-850
32. Roselli M, Carocci A, Budriesi R, Micucci M, Toma M, Di Cesare Mannelli L, Lovece A, Catalano A, Cavalluzzi MM, Bruno C, De Palma A, Contino M, Perrone MG, Colabufo NA, Chiarini A, Franchini C, Ghelardini C, Habtemariam S, Lentini G., Synthesis, antiarrhythmic activity, and toxicological evaluation of mexiletine analogues, Eur J Med Chem., 2016; 121: 300-7
33. Micucci M, Angeletti A, Cont M, Corazza I, Aldini R, Donadio E, Chiarini A, Budriesi R., Hibiscus Sabdariffa L. Flowers and Olea Europea L. Leaves Extract-Based Formulation for Hypertension Care: In Vitro Efficacy and Toxicological Profile, J Med Food.,  2016 ;19(5):504-12
34. Carosati E, Cosimelli B, Ioan P, Severi E, Katneni K, Chiu FC, Saponara S, Fusi F, Frosini M, Matucci R, Micucci M, Chiarini A, Spinelli D, Budriesi R., Understanding Oxadiazolothiazinone Biological Properties: Negative Inotropic Activity versus Cytochrome P450-Mediated Metabolism, J Med Chem.,  2016; 59(7): 3340-52
35. Claudia Brizi, Chiara Santulli, Matteo Micucci, Roberta Budriesi, Alberto Chiarini, Carlo Aldinucci, Frosini Maria, Neuroprotective effects of Castanea sativa Mill. bark extract in human neuroblastoma cells subjected to oxidative stress, J Cell Biochem. 2016; 117(2): 510-20.
36. Micucci M, Malaguti M, Gallina Toschi T, Di Lecce G, Aldini R, Angeletti A, Chiarini A, Budriesi R, Hrelia S., Cardiac and Vascular Synergic Protective Effect of Olea europea L. Leaves and Hibiscus sabdariffa L. Flower Extracts, Oxid Med Cell Longev.,  2015;2015:318125
37. Spinelli D, Budriesi R, Cosimelli B, Severi E, Micucci M, Baroni M, Fusi F, Ioan P, Cross S,   Frosini M, Saponara S, Matucci R, Rosano C, Viale M, Chiarini A, Carosati E., Playing with opening and closing of heterocycles: using the cusmano-ruccia reaction to develop a novel class of oxadiazolothiazinones, active as calcium channel modulators and p-glycoprotein inhibitors, Molecules, 2014, 19(10): 16543-72
38. Aldini R, Micucci M, Cevenini M, Fato R, Bergamini C, Nanni C, Cont M, Camborata C, Spinozzi S, Montagnani M, Roda G, D'Errico-Grigioni A, Rosini F, Roda A, Mazzella G, Chiarini A, Budriesi R., Antiinflammatory effect of phytosterols in experimental murine colitis model: prevention, induction, remission study, PLoS One, 2014, 9(9): e108112
39. Randolph RJ Arroo, Kenneth Beresford, Avninder Bhambra, Mike Boarder, Roberta Budriesi, Zhong Cheng, Matteo Micucci, Ketan Ruparelia, Somchaiya Surichan, Vasilis Androutsopoulos, Phytoestrogens as natural prodrugs in cancer prevention: Towards a mechanistic model, Phytochemistry Reviews, 2014, 1-14
40. Micucci M, Ioan P, Aldini R, Cevenini M, Alvisi V, Ruffilli C, Chiarini A, Budriesi R., Castanea sativa Mill. Extract Contracts Gallbladder and Relaxes Sphincter of Oddi in Guinea Pig: A Natural Approach to Biliary Tract Motility Disorders, J Med Food, 2014, 17(7): 795-803
41. Micucci M, Aldini R, Cevenini M, Colliva C, Spinozzi S, Roda G, Montagnani M, Camborata C, Camarda L, Chiarini A, Mazzella G, Budriesi R., Curcuma longa L. as a therapeutic agent in intestinal motility disorders. 2: Safety profile in mouse, PLoS One, 2013, 8(11): e80925
42. Fumagalli, Laura; Pallavicini, Marco; Budriesi, Roberta; Bolchi, Cristiano; Canovi, Mara; Chiarini, Alberto; Chiodini, Giuseppe; Gobbi, Marco; Laurino, Paola; Micucci, Matteo; Straniero, Valentina; Valoti, Ermanno, 6-Methoxy-7-benzofuranoxy and 6-methoxy-7-indolyloxy analogues of 2-[2-(2,6-dimethoxyphenoxy)ethyl]aminomethyl-1,4-benzodioxane (WB4101): discovery of a potent and selective α-adrenoceptor antagonist, J Med Chem., 2013, 56(16):6402-12
43. Catalano,A.; Budriesi, R.; Bruno, C.; Di Mola, A.; Defrenza, I.; Cavalluzzi, M. M.; Micucci, M.; Carocci,A.; Franchini, C.; Lentini, G. Searching for new antiarrhythmic agents: evaluation of meta-hydroxymexiletine enantiomers, Eur J Med Chem, 2013, 18;65C:511-516
44. Locatelli A, Cosconati S, Micucci M, Leoni A, Marinelli L, Bedini A, Ioan P, Spampinato SM, Novellino E, Chiarini A, Budriesi R., Ligand Based Approach to L-Type Calcium Channel by Imidazo[2,1-b]thiazole-1,4-Dihydropyridines: from Heart Activity to Brain Affinity, J Med Chem, 2013, 56(10):3866-77
45. Chiarini, A.; Micucci, M.; Malaguti, M.; Budriesi, R.; Ioan, P.; Lenzi, M.; Fimognari, C.; Gallina Toschi, T.; Comandini, P.; Hrelia, S. Sweet Chestnut (Castanea Sativa Mill.) bark extract: cardiovascular activity and myocyte protection against oxidative damage, Oxid Med Cell Longev, 2013, 2013; 2013:471790
46. Fumagalli, L.; Pallavicini, M.; Budriesi, R.; Gobbi, M.; Straniero, V.; Zagami, M.; Chiodini, G.; Bolchi, C.; Chiarini, A.; Micucci, M.; Valoti, E. Affinity and activity profiling of unichiral 8-substituted 1,4-benzodioxane analogues of WB4101 reveals a potent and selective alpha 1B-adrenoceptor antagonist, Eur J Med Chem, 2012, 58, 184-191
47. Aldini, R.; Budriesi, R.; Roda, G.; Micucci, M.; Ioan, P.; D’Errico-Grigioni, A.; Sartini, A.; Guidetti, E.; Marocchi, M.; Cevenini, M.; Rosini, F.; Montagnani, M.; Chiarini, A.; Mazzella, G. Effect of Curcuma longa extract on the intestinal motility in acute and chronic DSS induced colitis in mice, Plose One, 2012, 7, e44650, pp12
48. Carosati, E.; Ioan, P.; Micucci, M.; Broccatelli, F.; Cruciani, G.; Zhorov, B. S.; Chiarini, A.; Budriesi, R. 1,4-Dihydropyridine Scaffold in Medicinal Chemistry, The Story so Far And Perspectives. (Part 2): Action in Other Targets and Antitargets, Curr Med Chem, 2012, 19, 4306-4323.
49. Ioan, P.; Carosati, E.; Micucci, M.; Cruciani, G.; Broccatelli, F.; Zhorov, B. S.; Chiarini, A.; Budriesi, R. 1,4-Dihydropyridine Scaffold in Medicinal Chemistry, The Story so Far And Perspectives. (Part 1): Action in Ion Channels and GPCRs., Curr Med Chem, 2011, 18, 4901-4922.
50. Cosimelli, B.; Severi, E.; Novellino, E.; Cavaccini, A.; Cataldi, M.; Budriesi, R.; Micucci, M.; Chiarini, A.; Ioan, P. Preliminary Finding on a New Calcium Channel Entry Blocker Chemotype: 5,6-Diamino-4-hydroxy-2-mercaptopyrimidine Derivatives, J Med Chem, 2011, 54, 5597-5601.
51. Budriesi, R.; Ioan, P.; Leoni, A.; Pedemonte, N.; Locatelli, A.; Micucci, M.; Chiarini, A.; L. J. Galietta. Cystic Fibrosis: a New Target for 4-Imidazo[2,1-b]thiazole-1,4- Dihydropyridines, J Med Chem, 2011, 54, 3885-3094.
52. Budriesi, R.; Ioan, P.; Micucci, M.; Micucci, E.; Limongelli, V.; Chiarini, A. Stop Fitan: Antispasmodic Effect of Natural Extract of Chestnut Wood in Guinea Pig Ileum and Proximal Colon Smooth Muscle, J Med Food, 2010, 13, 1104-1110.
53. Tasso, B.; Budriesi, R.; Vazzana, I.; Ioan, P.; Micucci, M.; Novelli, F.; Tonelli, M.; Sparatore, A.; Chiarini, A.; Sparatore, F.; Novel Quinolizidinyl Derivatives as Antiarrhythmic Agents: 2. Further Investigation, J Med Chem, 2010, 53, 4668-4677.

Ho redatto una parte del libro “La Chimica e gli alimenti- nutrient e aspetti nutraceutici” Casa Editrice Ambrosiana. Distribuzione esclusiva Zanichelli, 2019

Ho scritto il libro "Ipertensione e aterosclerosi - il nuovo paradigma della Nutraceutica", 2021